Get a lay of the land (and sky)
If you have never been to San Francisco before, I would recommend starting out with the awesome and extremely knowledgeable folks from the SF architecture walking tours. Although it would be common sense to just walk around and take a look yourself, the tours take you to rooftop gardens, hidden murals and provide a wealth of knowledge about the city and its history. Learn about the Great 1906 earthquake and its aftermath. Learn about the construction of the infamous Transamerica pyramid. Hear how the gold rush financed the construction of the city by the bay!
Beginning in the downtown area, Architecture Walking Tours will lead you through the financial district as well. Just two hours long, the tours start at both 11 am and 3 pm every day. The tours are $20 (cash only) and reservations are encouraged. Meet at the Galleria Park Hotel, on Sutter street to begin the tour!
http://www.architecturesf.com/index.html
Galleria Park Hotel
191 Sutter Street, San Francisco, CA, 94104, US
415-781-3060